Crypt
Only drops in Crypt (floors 10–20, and again every 120 floors).
Echo Blade
Your ability stores two charges that carry over between floors: use one and save the other for the boss.
Helm of the Returned
Once per run, when you die you get back up with 30% life.
Boots of the Descent
+6% damage for each floor you go down in this run (up to +60%).
Ossuary Key
At each door you choose between three instead of two.
Swamp
Only drops in Swamp (floors 21–40, and again every 120 floors).
Hydra's Stinger
The Arrow Rain fires 12 arrows instead of 8 and each adds 2 stacks; against bosses, poison has no cap.
Apothecary's Gloves
If your weapon isn't poison, every hit poisons (2 stacks) and that poison deals triple damage.
Witch's Necklace
Poison no longer has a stack cap and deals double damage; your hits poison with 2 stacks.
Swamp Sash
Poison stacks aren't lost: every enemy on the next floor inherits them.
Forge
Only drops in Forge (floors 41–60, and again every 120 floors).
Anvil Hammer
Every mace hit sets the enemy ablaze; the burn grows 10% with each consecutive hit.
Cinder Cuirass
Whoever hits you burns: 50% of the damage they dealt is added to their burn.
Slag Pauldrons
Burns stack up to 5 times and last twice as long; +20% burn chance.
Eternal Ember
Your ability charges on its own over time (35% per second), but your hits no longer charge it.
Glacier
Only drops in Glacier (floors 61–80, and again every 120 floors).
Heart of Winter
The Orb freezes everyone for 3 s and deals no damage; while they're frozen, your hits deal triple damage.
Frost Rampart
When you're hit, 50% chance to freeze the attacker for 3 s.
Queen's Signet
Each time you freeze an enemy, +50% attack speed for 6 s.
Glacier Greaves
Bosses no longer halve the freeze and your freezes last 50% longer.
Bastion
Only drops in Bastion (floors 81–100, and again every 120 floors).
Captain's Fang
Every fourth hit is a guaranteed crit; crits double the bleed.
Iron Fists
+15% crit chance, and your crits charge your ability triple.
Faceless Helm
Your max life is halved and all your damage rises 150%.
Ogre's Belt
1% of your max life is added to the damage of every hit: life hits too.
Abyss
Only drops in Abyss (floors 101–120, and again every 120 floors).
Spear of the Four Wounds
Drops with a school, like other weapons. The Thrust causes bleed, burn, freeze and poison at once.
Eye of the Waiting One
Your ability charges 40% faster and can keep charging up to 200% (double damage).
Amulet of the Four Schools
Affixes from other schools count for half toward yours: almost all loot is useful to you.
Mantle of the Void
At the start of each floor, a shield worth 8% of your life absorbs the first hits.